Comparison of Oseltamivir and Oseltamivir Carboxylate Concentrations in Venous Plasma,Venous Blood,and Capillary Blood in Healthy Volunteers |
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| Authors: | Insti Instiaty Niklas Lindegardh Podjanee Jittmala Warunee Hanpithakpong Daniel Blessborn Sasithon Pukrittayakamee Nicholas J. White Joel Tarning |
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| Affiliation: | Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailanda;Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailandb;Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdomc |
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| Abstract: | Oseltamivir and oseltamivir carboxylate concentrations were measured in venous plasma, venous blood, and capillary blood taken simultaneously from 24 healthy volunteers. Median (range) venous-blood-to-plasma ratios were 1.42 (0.920 to 1.97) for oseltamivir and 0.673 (0.564 to 0.814) for oseltamivir carboxylate. Capillary blood/venous plasma ratios were 1.32 (0.737 to 3.16) for oseltamivir and 0.685 (0.502 to 1.34) for oseltamivir carboxylate. Oseltamivir concentrations in venous and capillary blood were similar. Oseltamivir carboxylate showed a time-dependent distribution between venous and capillary blood. |
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