In Vivo Efficacy of Daptomycin against Methicillin-Resistant Staphylococcus aureus in a Mouse Model of Hematogenous Pulmonary Infection |
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| Authors: | Yosuke Harada Katsunori Yanagihara Koichi Yamada Yohei Migiyama Kentaro Nagaoka Yoshitomo Morinaga Shigeki Nakamura Yoshifumi Imamura Hiroo Hasegawa Taiga Miyazaki Koichi Izumikawa Hiroshi Kakeya Shigeru Kohno |
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| Affiliation: | Department of Laboratory Medicinea;Second Department of Internal Medicine,b Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;Global COE Program, Nagasaki University, Nagasaki, Japanc |
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| Abstract: | Daptomycin is inactivated by pulmonary surfactant, but its effectiveness in hematogenous pulmonary infection has been poorly studied. The potential therapeutic application was evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) hematogenous pulmonary infection mouse model. Compared with control results, daptomycin improved survival (P < 0.001) and decreased the number of abscesses and bacteria in the lungs (P < 0.01). Daptomycin may be an effective therapeutic option for MRSA hematogenous pulmonary infection. |
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