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Molecular Characterization of blaNDM-1 in a Sequence Type 235 Pseudomonas aeruginosa Isolate from France |
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| Authors: | Frédéric Janvier Katy Jeannot Sophie Tessé Marjorie Robert-Nicoud Hervé Delacour Christophe Rapp Audrey Mérens |
| Affiliation: | Service de Microbiologie-Hygiène, Hôpital d''Instruction des Armées Bégin, Saint-Mandé, Francea;Centre National de la Résistance aux Antibiotiques, Laboratoire de Bactériologie, Hôpital Jean Minjoz, Besançon, Franceb;Service de Maladies Infectieuses et Tropicales, Hôpital d''Instruction des Armées Bégin, Saint-Mandé, Francec |
| Abstract: | An NDM-1 carbapenemase-producing Pseudomonas aeruginosa isolate was recovered from a patient hospitalized in France after a previous hospitalization in Serbia. Genetic studies revealed that the blaNDM-1 gene was surrounded by insertion sequence ISAba125 and a truncated bleomycin resistance gene. This blaNDM-1 region was a part of the variable region of a new complex class 1 integron bearing IS common region 1 (ISCR1). The presence of ISPa7 upstream of this integron suggests insertion in a chromosomally located Tn402-like structure. |
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