| sgp130对糖尿病小鼠视网膜p-STAT3及VEGF-A表达的影响 |
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| 引用本文： | 刘光辉,史常旋,洪雅军,郑永征,王航,孟春.sgp130对糖尿病小鼠视网膜p-STAT3及VEGF-A表达的影响[J].国际眼科杂志,2023,23(3):375-378. |
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| 作者姓名： | 刘光辉 史常旋 洪雅军 郑永征 王航 孟春 |
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| 作者单位： | 中国福建省福州市,福建中医药大学附属人民医院眼科; 中国福建省福州市,福建中医药大学中西医结合眼科研究所,中国福建省福州市,福州大学生物科学与工程学院,中国福建省福州市,福州大学生物科学与工程学院,中国福建省福州市,福建中医药大学附属人民医院眼科; 中国福建省福州市,福建中医药大学中西医结合眼科研究所,中国福建省福州市,福建中医药大学中西医结合眼科研究所; 中国福建省福州市,福州大学生物科学与工程学院,中国福建省福州市,福建中医药大学中西医结合眼科研究所; 中国福建省福州市,福州大学生物科学与工程学院 |
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| 基金项目： | 国家自然科学基金面上项目(No.81774369); 福建省卫生健康中青年科研重大项目(No.2021ZQNZD012) |
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| 摘 要： | 目的:观察可溶性糖蛋白130(sgp130)对糖尿病(DM)小鼠视网膜p-STAT3及VEGF-A表达的影响，探讨sgp130防治糖尿病视网膜病变(DR)炎性损害的可能性。方法:小鼠45只被随机分为正常组、DM组和sgp130组。采用链脲佐菌素对DM组和sgp130组进行DM造模。正常组、DM组不做特殊干预，sgp130组在第1、5wk被给予1.5mg/mL sgp130 2μL进行玻璃体腔注射治疗。10wk后处死所有小鼠，检查视网膜组织IL-6、p-STAT3、VEGF-A等蛋白的表达。结果:在第10wk时，DM组视网膜IL-6、p-STAT3、VEGF-A表达较正常组升高(均P<0.01)。sgp130组p-STAT3、VEGF-A表达水平较DM组低(均P<0.01)。结论:sgp130可以选择性拮抗IL-6反式信号传导通路，下调下游炎性因子VEGF-A的表达，可以用于干预DM引起的IL-6相关性视网膜炎性损害。
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| 关 键 词： | 糖尿病视网膜病变 炎症 白介素6 p-STAT3 血管内皮生长因子A(VEGF-A) 可溶性糖蛋白130(sgp130) |
| 收稿时间： | 2022/4/12 0:00:00 |
| 修稿时间： | 2023/2/15 0:00:00 |
Effects of soluble glycoprotein 130 on expression of p-STAT3 and vascular endothelial growth factor-A in retina of mice with diabetes mellitus |
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| Guang-Hui Liu,Chang-Xuan Shi,Ya-Jun Hong,Yong-Zheng Zheng,Hang Wang and Chun Meng.Effects of soluble glycoprotein 130 on expression of p-STAT3 and vascular endothelial growth factor-A in retina of mice with diabetes mellitus[J].International Journal of Ophthalmology,2023,23(3):375-378. |
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| Authors: | Guang-Hui Liu Chang-Xuan Shi Ya-Jun Hong Yong-Zheng Zheng Hang Wang and Chun Meng |
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| Institution: | Department of Ophthalmology, Affiliated People''s Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China; Eye Institute of Integrated Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China,College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China,College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China,Department of Ophthalmology, Affiliated People''s Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China; Eye Institute of Integrated Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China,Eye Institute of Integrated Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China; College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China and Eye Institute of Integrated Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China; College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China |
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| Abstract: | |
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| Keywords: | diabetic retinopathy inflammation interleukin 6 p-STAT3 vascular endothelial growth factor-A(VEGF-A) soluble glycoprotein 130(sgp130) |
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