An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases |
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Authors: | Faridoon Nazar Ul Islam |
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Affiliation: | 1.Chemistry Department, Islamia College University, Peshawar-25120, Pakistan.;2.Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan. |
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Abstract: | The production of metallo-β-lactamases is the most important strategy by which pathogenic bacteria become resistant to currently known β-lactam antibiotics. The emergence of these enzymes is particularly concerning for the future treatment of bacterial infections. There are no clinically available drugs capable of inhibiting any of the metallo-β-lactamases, so there is an urgent need to find such inhibitors. In this review, an up-to-date status of the inhibitors investigated for the inhibition of metallo-β-lactamases has been given so that this rich source of structural information of presently known metallo-β-lactamases could be helpful in generating a broad-spectrum potent inhibitor of metallo-β-lactamases. |
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Keywords: | Metallo-beta-lactamases, Inhibition, Thiol, β -Lactam analogues, Peptides, Biphenyl tetrazoles, Triazoles |
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