压宁定对高血压病人血压和甲状旁腺升压因子及降钙素基因相关肽的影响

目的观察压宁定对高血压病人血压、降钙素基因相关肽（ＣＧＲＰ）和甲状旁腺升压因子（ＰＨＦ）的影响。②方法对３５例高血压病人口服压宁定治疗５６ｄ，用放射免疫分析法测定治疗前后血压、血浆ＰＨＦ，ＣＧＲＰ含量，并与对照组（３２例）进行比较。③结果压宁安治疗前，高血压病人血浆ＰＨＦ较对照组高（ｔ＝２．０８２，Ｐ＜０．０５），ＣＧＲＰ低于对照组（ｔ＝２．８３０，Ｐ＜０．０１）。压宁定治疗后，病人血浆ＰＨＦ明显降低（ｔ＝２．９７６，Ｐ＜０．０５）；ＣＧＲＰ明显升高（ｔ＝２．１２８，Ｐ＜０．０１）；收缩压及舒张压均明显降低（ｔ＝２．８１６，２．０８５，Ｐ均＜０．０１），降压总有效率为９４．３％．④结论压宁定降压效果肯定，对ＰＨＦ和ＣＧＲＰ有较好的改善作用。

EFFECT OF URAPIDIL ON BLOOD PRESSURE, PARATHYROID GLAND HEMOPIESIC FACTOR AND CALCITONIN GENE RELATED PEPTIDE OF HYPERTENSION PATIENTS

Objective\ To observe urapidil's effect on blood pressure, calcitonin gene related peptide (CGRP) and parathyroid gland hemopiesic factor (PHF) of hypertension patients.\ Methods\ 35 hypertension patients were treated with urapidil for 56 days. The blood pressure, plasma PHF and CGRP in 35 hypertension patients were measured with radioimmunoassay before and after treatment and the comparison with the control group ( n =32) was made.\ Results\ Before treatment, the plasma PHF in hypertension patients was significantly higher ( t=2.082,P <0.05) and CGRP was significantly lower in comparison with the control group ( t=2.830,P <0.01). After treatment with urpaidil, the plasma PHF decreased markedly ( t=2.976,P < 0.05 ), CGRP increased significantly ( t=2.128,P <0.01); Systolic pressure and diastolic pressure dropped markedly ( t=2.816, 2.085 ,P <0.01) and the total efficiency of reducing pressure was 94.3%.\ Conclusion\ Urapidil has positive effect on reducing pressure and good improving effect on PHF and CGRP.