缺血性心脏病患者C-反应蛋白的变化及临床意义

目的 :观察缺血性心脏病 (IHD)时血清中C -反应蛋白 (CRP)的变化 ,以探讨CRP与IHD的关系及临床意义。方法 :选择体检健康者 3 0例、心绞痛患者 45例、急性心肌梗死患者 3 0例各作为正常对照 (C)组、心绞痛 (AP)组和急性心肌梗死 (AMI)组。C组于清晨、AP组于入院次日清晨取血 ,而AMI组于发病 6、12、2 4、48及 72h取血。采用散射比浊法检测CRP。结果 :AP组及AMI组各时间点CRP较C组显著增高 (P <0 0 1) ;AMI组各时间点CRP较AP组显著增高 (P <0 0 5 ) ;CRP在急性心肌梗死后的 72h内呈明显动态变化 ,6h开始升高 ,48h达高峰 ,后渐下降 ,72h时仍明显高于正常。结论 :CRP参与IHD的发病过程 ,其水平的高低与IHD的严重程度有关 ,急性心肌梗死时CRP动态演变具有判断病情发展趋势和预后的价值。

THE CHANGES AND CLINICAL SIGNIFICANCE OF C-REACTIVE PROTEIN IN ISCHEMIC HEART DISEASE

Objective:To study the relation ship of inflammation markers-CRP (C-reactive protein) to ischemic heart disease and the clinical significance.Methods:30 persons were selected as control group(group C),45 patients as agina pectoris group(group AP),30 patients as acute myocardium infarction group(group AMI).The blood sample of the group C and group AP were drawn from venous in the morning of the second day after hospitalized,group AMI were drown at the point of 6,12,24,48 and 72h after episode.The concentration of CRP is determined by Scatter Turbidimetry.Results:The levels of CRP in group AP and group AMI were significantly higher than group C (P<0.01),and group AMI were significantly higher than group AP (P<0.05),the levels of CRP in group AMI appear significantly development changes during 72h after AMI.Conclusions:CRP take part in the course of IHD.The levels of CRP in serum are related to the seriousness of IHD.The development changes of CRP during AMI can be valued as an index for determining the patient's tendency and prognosis.