中药和天然药靶向制剂的研究进展

靶向制剂可以提高靶组织的药理作用强度和降低全身的不良反应 ,是一种比较理想的给药方式 ,为第四代的药物剂型。采用脂质体作为药物载体是研究的重点 ,磁靶向 ,酶靶向制剂也是研究热点。此外 ,口服结肠靶向给药系统 (OCDDS)也是靶向制剂的一个重要部分 ,其是经口服将药物运送到回盲肠后释放并发挥局部或全身的治疗作用。中药靶向制剂的研究在我国还仅处于试探阶段 ,目前中药和天然药物的靶向制剂的研究大多数是以天然单一有效成分为原料药物 ,而用中药有效部位研制的靶向制剂屈指可数 ,这与制定中药有效部位的质量标准及制剂工艺难度大有关。中药新剂型和新技术的开展是中药国际化的关键 ,需要有组织地开展多学科合作 ,靶向制剂是中药今后发展的一个重要课题。

Advances in the Research on Targeted Preparations of Traditional Chinese Medicine and Natural Drugs

Objective: Targeting dosage form is a kind of targeting drug delivery system which can be used to lock drugs aroud the target organs, tissues, cells and obtain more effective treatment for dose concentration,thus reducing the side effects of such drugs while increasing their effeciveness. Targeting dosage form is the fourth generation drug dosage form and it is ideal system for administratiom because it release the theraping drugs in the targeting site. Particular emphasis was placed on liposome due to it was used as a drug carrier. Meanwhile, the highlights of research were on magnetic and enzyme targeting preparations. In addition, oral colon targeting drug delivery system, drugs were carried to ileocecum and release to get local and whole effect, is also an important part of targeting dosage form. The study on traditional chinese medicine (TCM) targeting dosage form is still at beginning stage in China. At present,most of study on TCM and natural products targeting drugs were focus on simple effective component and merely on TCM effective positions in relative with the difficult for determing their quality standard and procedure of preparing .It is the kernel item for TCM modernization and the key for TCM internationalization to develop new dosage form and new technology of TCM. There is a need in collaboration with multiple discipline. It will be a important research subject to develop TCM targeting preparation in the near future. TCM targeting dosage form can be classified into liposome, nanoparticles, multiple emulsion etc according to the difference of carrier and oral, rectal, colonic,. nasal, dermal , ocular system on a basis of administration and so on. This paper made a summary on TCM and natural products targeting dosage form according to different targeting positions and introduce the procedure of preparing compared with the effect in vivo and manifest that TCM and natural products targeting dosage form will have good exploit prospect.targeting site .Particularemphasiswasplacedonliposomeduetoitwasusedasa drugcarrier.Meanwhile,thehighlightsofresearchwereonmagneticandenzymetargetingpreparations .Inaddition ,oralcolontar getingdrugdeliverysystem ,drugswerecarriedtoileocecumandreleasetogetloca