| p42／p44^MAPK和cyclin D1蛋白在霍奇金病中的表达及其相互关系 |
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| 引用本文： | 黎岳南,郑晖.p42／p44^MAPK和cyclin D1蛋白在霍奇金病中的表达及其相互关系[J].湖南医科大学学报,2000,25(1):6-8. |
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| 作者姓名： | 黎岳南 郑晖 |
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| 摘 要： | 利用ＳＰ免疫组织化学方法检测了４０例不同类型霍奇金病９ＨＤ）ＲＨ／Ｓ细胞及１３例反应性增生淋巴结（ＲＨ）的ｐ４２／ｐ４４＾ＭＡＰＫ和ｃｙｃｌｉｎ Ｄ１蛋白的表达。结果显示；ｐ４２／ｐ４４＾ＭＡＰＫ及ｃｙｃｌｉｎ Ｄ１蛋白在ＨＤ之ＲＳ／Ｈ细胞中均呈过度表达，且两者阳性率呈明显的正相关，提示ＭＡＰＫ级联信号转导在ＨＤ发生中起重要作用，并通过诱导ｃｙｃｌｉｎ Ｄ１蛋白高表达使ＲＳ／Ｈ细胞持续增殖及演进。
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| 关 键 词： | 何杰金氏病 淋巴瘤 信号转导 癌基因蛋白 |
The expression of p42/p44MAPK and cyclin D1 protein and their relationship in Hodgkin's disease] |
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| Y N Li,H Zheng,H Y Jiang,D Y Feng.The expression of p42/p44MAPK and cyclin D1 protein and their relationship in Hodgkin''s disease][J].Bulletin of Hunan Medical University,2000,25(1):6-8. |
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| Authors: | Y N Li H Zheng H Y Jiang D Y Feng |
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| Institution: | Department of Pathology, Hunan Medical University, Changsha 410078. |
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| Abstract: | The expressions of p42/44 mitogen-activated protein kinase(p42/p44MAPK) and cyclin D1 protein were detected by SP immunohistochemical technique in 40 cases of Hodgkin's disease(HD) and 13 cases of reactive hyperplasia(RH). The results showed that p42/p44MAPK and cyclin D1 protein were both overexpressed in RS/H cells of HD(positive rates were 72.5% and 70% respectively), and their positive rates were positively correlated(P < 0.01). The data suggest that MAPK cascades signal transduction may play an important role in genesis of HD. MAPK may induce overexpression of cyclin D1 protein and result in persistent proliferation and progression of RS/H cells. |
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