长托宁治疗急性有机磷农药中毒(附78例报告)

目的评价长托宁治疗急性有机磷农药中毒(AOPP)的疗效、不良反应及阿托品化的影响。方法长托宁联合氯磷定治疗78例AOPP(长托宁组);阿托品联合氯磷定治疗67例AOPP(阿托品组)。比较2组的治疗效果。结果长托宁组的M样、N样及中枢神经系统中毒症状持续的时间、胆碱酯酶活力恢复时间均较阿托品组明显缩短(<0.01);用药过量出现中毒发生率显著低于阿托品组(<0.01);长托宁组尿潴留、窦性心动过速的发生率显著低于阿托品组(<0.01);长托宁组住院时间(5.48d)与阿托品组(9.13d)比有显著性差异(<0.01)。结论长托宁是一种比阿托品效果好、不良反应少的抗胆碱药,可取代阿托品救治AOPP。

Clinical Application of Changxiaotuoning on Cases of Acute Organophosphorus Pesticide Poisoning

Objective To evaluate thetreatmenteffect,adverse reactionand atropinization ofChangxiaotuoning and Atropine on acute organophosphorus poisoning(AOPP)patients.Methods 78 AOPP patients in Changxiaotuoning groupweretreated with Changxiaotuoning and Pyraloximechloride.67 such patientsin Atropinegroup were treatedwith Atropine and Pyraloxime chloride.The treatment effect of the two groups were compared.Results Compared with Atropine group,duration of oxycholine,nicotine,central nervous system toxic symptom and duration of the recovery of cholinesterase(ChE)activity were obviously shorte(r <0.01)than in Changxiaotuoning group.Toxic rate of over ad-ministration in Changxiaotuoning group was lower than that in Atropine group(<0.01).Dry mouth and restlessness appeared in Changxiaotuoning group,but adverse reaction of urinary retention and sinus tachycardia were significantly lower than in Atropine group(<0.01).Length of hospitalization in Changxiaotuoning group(5.48d)and Atropine group(9.13d)wassignificantly differen(t <0.01).Conclusion Changxiaotuoningisbetter than Atropine.It canreplace Atro-pine in the treatment of AOPP.