乙型肝炎肝硬化患者血清铁和铁蛋白水平与脂质过氧化损伤的相关性研究

目的探讨乙型肝炎肝硬化患者血清铁（SI）、铁蛋白（FE）水平与脂质过氧化损伤的关系。方法选择61例不同Child-Pugh分级的乙型肝炎肝硬化患者,采用采用比色法检测SI,放射免疫法检测FE,黄嘌呤氧化酶法检测超氧化物歧化酶（SOD）和硫代巴比妥酸法检测丙二醛（MDA）。结果乙型肝炎肝硬化患者血清SI和FE水平均明显高于对照组;SI、FE、MDA水平依Child-Pugh分级而呈上升趋势,而SOD水平则依次降低;SI和FE水平与MDA水平均呈正相关（r=0.562,P〈0.01;r=0.535,P〈0.01）,与SOD水平均呈负相关（r=-0.429,P〈0.01;r=-0.422,P〈0.01）。结论乙型肝炎肝硬化患者血清SI和FE水平与脂质过氧化损伤有相关性,过重铁负荷加重了肝细胞损害。

The relationship of serum iron,ferritin and lipid peroxidation injury in patients with hepatitis B-induced liver cirrhosis

Objective To investigate the relationship between serum iron,ferritin and lipid peroxidation injury in patients with hepatitis B-induced liver cirrhosis. Method 61 patients with hepatitis B cirrhosis were enrolled in this study. Serum iron was detected by chromatometry,ferritin by radioimmunoassay,malondialdehyde by thiobarbituric acid method,and superoxide dismutase by xanthine oxidase method. Results Serum iron and ferritin levels in patients with liver cirrhosis were higher significantly than that in control group. Serum iron,ferritin and malondialdehyde levels increased,and the superoxide dismutase level decreased as the liver function of Child-Pugh class deteriorated;serum iron and ferritin were significantly positively correlated with malondialdehyde （r=0.562,P〈0.01;r=0.535,P〈0.01）,and negatively with superoxide dismutase （r=-0.429,P〈0.01;r=-0.422,P〈0.01）. Conclusion There are significant correlation between serum iron,ferritin and lipid peroxidation injury in patients with liver cirrhosis. The overload of iron may enhance the hepatocyte damage.