甲状腺乳头状腺癌中血管内皮生长因子-C和CD34的表达及其临床意义

目的 探讨甲状腺乳头状腺癌中血管内皮生长因子-C(VEGF-C)、CD34表达及其临床意义.方法 61例原发性甲状腺肿瘤(乳头状腺癌38例,腺瘤23例)分别应用免疫组化方法 检测VEGF-C及CD34表达情况.结果 VEGF-C及CD34在各甲状腺肿瘤及间质组织均存在表达,腺癌组VEGF-C(38.24±19.58)显著高于腺瘤组(16.49±9.25)(t=4.9889,P<0.01),腺癌组CD34表达量[(23.68±9.07)个/HP]高于腺瘤组[(18.70±6.34)个/HP](t=2.3102,P<0.05);ⅦGF-C在肿瘤有转移(46.35±17.68)、瘤体>3 cm(44.25±20.67)患者中表达高于肿瘤无转移(27.14±10.57)及瘤体≤3 cm 组(30.81±13.43)(t值分别为4.2082及2.4252,P<0.05或P<0.01);CD34在肿瘤有转移[(29.63±12.52)个/HP]、瘤体>3 cm[(28.35±11.23)个/HP]及年龄>40岁[(26.24±9.83)个/HP]患者中含量高于无转移[(18.22±5.87)个/HP]、瘤体≤3 cm[(19.46±7.55)个/HP]及年龄≤40岁组[(20.35±6.67)个/HP](t值分别为3.2103、2.9060及2.1364,P<0.01或P<0.05);VEGF-C与CD34呈显著正相关(r=0.46,P<0.01).结论 VEGF-C及CD34的表达与甲状腺肿瘤显著相关,检测VEGF-C及CD34水平对于鉴别甲状腺乳头状腺癌具有重要参考意义.

Abstract：

Objective To study the relationship between VEGF-C,CD34 expression and thyroid papillary tumor tissue by combining assays of VEGF-C and CD34 in thyroid tumor tissue.Methods The expression of VEGF-C and CD34 were dectected by immunohistochemistry in 61 cases(thyroid papillary cancer 38.thyroid adenoma 23).Results VEGF-C level in thyroid papillary cancer(38.24±19.58)were significantly hisher than that in thyroid adenoma(16.49±9.25,P<0.01);CD34 in thyroid papillary cancer (23.68 ±9.07)/HP were higher than that in thyroid adenoma(18.70±6.34,t=4.9889,P<0.01).We found a significant relationship between the VEGF-C expression and cancerometastasis or tumor size(P<0.01;P<0.05).There was also a relationship between the CD34 expression and cancerometastasis or tumor size or age (P<0.01 or P<0.05).There Was positive relationship between the expression of VEGF-C and CD34(r=0.46.P<0.01).Conclusion It is suggested that combined detections of VEGF-C and CD34 may have important reference value on the differential diagnosis between thyroid papillary tumor tissue.

Significance of VEGF-C and CD34 expression in thyroid papillary cancer tissue

Objective To study the relationship between VEGF-C,CD34 expression and thyroid papillary tumor tissue by combining assays of VEGF-C and CD34 in thyroid tumor tissue.Methods The expression of VEGF-C and CD34 were dectected by immunohistochemistry in 61 cases(thyroid papillary cancer 38.thyroid adenoma 23).Results VEGF-C level in thyroid papillary cancer(38.24±19.58)were significantly hisher than that in thyroid adenoma(16.49±9.25,P<0.01);CD34 in thyroid papillary cancer (23.68 ±9.07)/HP were higher than that in thyroid adenoma(18.70±6.34,t=4.9889,P<0.01).We found a significant relationship between the VEGF-C expression and cancerometastasis or tumor size(P<0.01;P<0.05).There was also a relationship between the CD34 expression and cancerometastasis or tumor size or age (P<0.01 or P<0.05).There Was positive relationship between the expression of VEGF-C and CD34(r=0.46.P<0.01).Conclusion It is suggested that combined detections of VEGF-C and CD34 may have important reference value on the differential diagnosis between thyroid papillary tumor tissue.