血中丙溴磷的测定及包膜活性炭和HA230树脂的灌流清除百分率

目的探讨包膜活性炭和HA230树脂对丙溴磷的灌流清除百分率，并比较其清除效果。方法分别用包膜活性炭和HA230树脂对中毒血样进行灌流吸附，将吸附后血样经乙酸乙酯萃取后，用毛细管气相色谱法检测并计算清除百分率。结果分析方法的检出限为0．8ng，低、中、高3种浓度的加标回收率为95．1％～101．2％，相对标准偏差为1．11％-10．97％。灌流吸附后血中丙溴磷的清除百分率在包膜活性炭为78．2％-85．8％，在HA230吸附树脂为84．5％-93．8％。结论用包膜活性炭和HA230树脂吸附剂进行血液灌流，均能迅速降低血中丙溴磷浓度。

Comparison between membrane coated activated charcoal and HA230 absorption resin for the clearance of profenofos in hemoperfusion

Objective To compare the clearance efficiencies of blood profenofos by hemoperfusion with membrane coated activated charcoal and HA230 absorption resin. Method Profenofos standard solutions were mixed with blood samples from healthy subjects, and the profenofos in blood samples was adsorbed by hemoperfusion through a column containing membrane coated activated charcoal or HA230 absorption resin. The remaining profenofos in blood was then extracted by ethylacetate and determined by capillary gas chromatography. Result The lowest limit for blood methamidophos measurement by this method was 0.8ng. The recovery rate to low, middle and high concentrations of blood profenofos was 95.1%-101.2%, with the relative standard deviation of 1.11%- 10.97%. By hemoperfusion using membrane coated activated charcoal column and HA230 absorption resin column, the clearance efficiencies were 78.2%-85.8% and 84.5%-93.8%, respectively. Conclusion Blood profenofos can be cleared efficiently and rapidly by hemoperfusion with membrane coated activated charcoal or HA230 absorption resin.