Characterization of a novel MICA allele,MICA*012:05, by cloning and sequencing |
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| Authors: | W. Y. Wang W. Tian F. Wang F. M. Zhu L. X. Li |
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| Affiliation: | 1. Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China;2. HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China;3. Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, China |
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| Abstract: | A new MICA allelic variant, MICA*012:05, has been identified in a Chinese Mongolian population. Following polymerase chain reaction–sequence‐based typing (PCR‐SBT), this new allele was further confirmed by cloning and sequencing. MICA*012:05 was linked to an HLA‐A*24‐C*01‐B*55:02‐DRB1*09 haplotype. MICA*012:05 differs from MICA*012:01 by a single synonymous C to T substitution at nucleotide position 269 in exon 3. |
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