Characterization of a novel HLA‐B*40 allele,HLA‐B*40:186:02, by cloning and sequencing |
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| Authors: | W Y Wang W Zhang J H Cai F M Zhu W Tian |
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| Institution: | 1. Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China;2. HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China;3. Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, China |
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| Abstract: | A novel HLA‐B*40 variant, HLA‐B*40:186:02, has been identified by cloning and sequencing in a southern Chinese Han population. Aligned with HLA‐B*40:01:01, HLA‐B*40:186:02 has a nonsynonymous cytosine mutation at nucleotide position 165 in exon 2, leading to amino acid change from glycine to arginine at codon 56. It differs from HLA‐B*40:186:01 by a synonymous change (adenine to cytosine) at position 165 in exon 2. |
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