ClC-3氯通道蛋白磷酸化及其功能的研究进展

细胞容积调节广泛参与细胞的各种生理病理过程,如上皮细胞物质转运、物质代谢、细胞兴奋性、激素释放、细胞迁移、细胞增殖及细胞坏死凋亡等1, 2].在低渗环境刺激下,容积激活性氯通道参与细胞容积调节,对维持细胞容积起着重要调节作用.

Progress in ClC-3 chloride channel phosphorylation and functions

ClC-3 channel is one of voltage-gated chloride channels for chloride ion transmembrane, and participates in a variety of physiological and pathological processes, such as cell volume regulation, proliferation, migration, apoptosis, organic release and acidification of synaptic vesicle. The ClC-3 channel is controlled by many factors, including phosphorylation and dephosphorylation, to regulate the opening and closing. PKA(protein kinase A), PKB, PKC and calcium calmodulin kinaseⅡ are the key kinases in cell signal transduction pathway, which take part in the processes of ClC-3 channel phosphorylation and regulate their functions. The study of ClC-3 phosphorylation and functions are helpful to understand the importance of ClC-3 in physiological and pathological processes and are premise to exploit the channel drugs for clinical therapy.