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| 环孢菌素A对大鼠腹主动脉球囊损伤后内膜增生的抑制作用 | |
| 引用本文： | 熊龙根,黎德恩,董颀.环孢菌素A对大鼠腹主动脉球囊损伤后内膜增生的抑制作用[J].中国病理生理杂志,2011,27(9):1687-1691. |
| 作者姓名： | 熊龙根 黎德恩 董颀 |
| 作者单位： | 1. 广州医学院第二附属医院心血管内科,广州心血管疾病研究所,广东 广州 510260; 2. 广州医学院生理教研室,广东 广州 510182 |
| 基金项目： | 广东省医学科学技术研究基金资助项目，广东省科技计划资助项目 |
| 摘 要： | 目的: 探讨环孢菌素A对大鼠腹主动脉球囊损伤后内膜增生的影响。方法: 雄性SD大鼠36只,随机分为假手术组(n=12)、球囊损伤组(n=12)和环孢菌素治疗组(n=12)。环孢菌素组大鼠行腹主动脉球囊损伤术前3 d开始每天灌喂环孢菌素A 12.5 mg/kg,假手术组和球囊损伤组灌喂等容积的水,直至术后30 d。球囊损伤术后30 d取材,血管组织作HE染色、免疫组化检测钙调神经磷酸酶(CaN)在血管壁中的表达,光学显微镜观察病理学改变;rea1-time PCR技术检测血管壁组织中CaN和活化T细胞核因子3(NFATc3)的表达变化。结果: 球囊损伤后血管壁出现新生内膜,形成的新生内膜厚度不均。环孢菌素治疗组与球囊损伤组相比较,内膜增生减轻,内膜/中膜厚度明显降低(P<0.05)。免疫组化检测血管壁上CaN表达,环孢菌素治疗组明显低于球囊损伤组 (P<0.05)。大鼠腹主动脉损伤后,损伤血管壁组织CaN和NFATc3 mRNA表达升高,环孢菌素治疗组与球囊损伤组相比表达明显减少(P<0.05)。结论: 环孢菌素A可能通过抑制CaN-NFATc途径减轻球囊扩张术后动脉再狭窄。 |
| 关 键 词： | 再狭窄 钙调神经磷酸酶 活化T细胞核因子 环孢菌素 |
| 收稿时间： | 2011-03-09 |
Cyclosporine A inhibits intima proliferation of rat abdominal aortas injured by balloon |
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| XIONG Long-gen,LI De-en,DONG Qi.Cyclosporine A inhibits intima proliferation of rat abdominal aortas injured by balloon[J].Chinese Journal of Pathophysiology,2011,27(9):1687-1691. | |
| Authors: | XIONG Long-gen LI De-en DONG Qi |
| Institution: | 1. Department of Cardiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510260, China; 2. Department of Physiology, Guangzhou Medical University, Guangzhou 510182, China. |
| Abstract: | AIM: To observe the effect of cyclosporine A on intima hyperplasia of rat abdominal aortas injured by balloon.METHODS: Thirty-six healthy adult male SD rats were randomly divided into 3 groups: sham group(n=12),balloon-injured group(n=12) and cyclosporine A treatment group(n=12).From the 3rd day before injury to the 30th day after injury,the rats in cyclosporine A treatment group were treated with cyclosporine A at a dose of 12.5 mg/kg everyday,while the rats in sham group and balloon-injured group were fed... |
| Keywords: | Restenosis Calcineurin Nuclear factors of activated T-cells Cyclosporine |
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