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| 妊娠合并急性胰腺炎大鼠胎盘组织细胞黏附分子E-选择素的表达及意义 | |
| 引用本文： | 徐丽南,林楠,张颖,蔡坚,王子莲. 妊娠合并急性胰腺炎大鼠胎盘组织细胞黏附分子E-选择素的表达及意义[J]. 中国病理生理杂志, 2011, 27(9): 1781-1785. DOI: 10.3969/j.issn.1000-4718.2011.09.023 |
| 作者姓名： | 徐丽南 林楠 张颖 蔡坚 王子莲 |
| 作者单位： | 1. 中山大学附属第一医院妇产科,广东 广州 510080; 2. 中山大学附属第三医院肝胆外科,广东 广州 510630 |
| 基金项目： | 广东省科技计划资助项目 |
| 摘 要： | 目的: 探讨细胞黏附分子E-选择素(E-selectin)在妊娠合并急性胰腺炎大鼠血清与胎盘组织中的表达水平及其与胎盘功能的关系。方法: 妊娠7 d大鼠胆胰管逆行注射5%牛磺胆酸钠,制作妊娠合并急性胰腺炎大鼠模型。分为正常妊娠组、妊娠合并急性胰腺炎1 h、4 h、8 h、12 h、24 h组(每组10例)。酶显色法测定血清脂肪酶水平,免疫分析法测定血清E-selectin浓度,逆转录聚合酶链反应技术及免疫印迹法检测胎盘组织E-selectin的 mRNA及蛋白表达。E-selectin水平与胰腺损伤评分、胎盘功能评分进行相关性分析。结果: 正常妊娠大鼠血清与胎盘组织内E-selectin呈低水平表达。妊娠合并胰腺炎12 h与24 h组血清E-selectin水平显著升高(P<0.05),胎盘组织E-selectin的 mRNA及蛋白表达明显增加(P<0.05); E-selectin 的升高与胰腺损伤程度(r=0.908)、胎盘功能损伤程度(r=0.803)呈正相关。 结论: 血清E-selectin的升高与胎盘组织损害相关;E-selectin可能参与了妊娠合并急性胰腺炎胎盘损伤的病理生理过程。 |
| 关 键 词： | 急性胰腺炎 妊娠 胎盘 黏附分子 E-选择素 大鼠 |
| 收稿时间： | 2011-04-05 |
Expression of adhesion molecule E-selectin in placenta tissues of pregnant rats with acute pancreatitis |
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| XU Li-nan,LIN Nan,ZHANG Ying,CAI Jian,WANG Zi-lian. Expression of adhesion molecule E-selectin in placenta tissues of pregnant rats with acute pancreatitis[J]. Chinese Journal of Pathophysiology, 2011, 27(9): 1781-1785. DOI: 10.3969/j.issn.1000-4718.2011.09.023 | |
| Authors: | XU Li-nan LIN Nan ZHANG Ying CAI Jian WANG Zi-lian |
| Affiliation: | 1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China; 2. Department of Hepatology Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. |
| Abstract: | AIM: To explore the role of E-selectin in the pathogenesis of acute pancreatitis in pregnant rats.METHODS: Pancreatitis was induced by retrograde injection of 5% sodium taurocholate through biliopancreatic duct.The animals were sacrificed in normal pregnancy group,and 1 h,4 h,8 h,12 h,24 h after induction of pancreatitis.The severity of pancreatitis was evaluated by detecting serum lipase and calculating pancreatic pathological score.Placenta injury was evaluated by pathological observation and serum E-sele... |
| Keywords: | Acute pancreatitis Pregnancy Placenta Adhesion molecule E-selectin Rats |
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