Computational simulations of mitral regurgitation quantification using the flow convergence method: Comparison of hemispheric and hemielliptic formulae |
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Authors: | Joanne Hopmeyer Erika Whitney Dana A Papp Manisha S Navathe Robert A Levine Young H Kim Ajit P Yoganathan |
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Institution: | (1) Cardiovascular Fluid Mechanics Laboratory, School of Chemical Engineering, Georgia Institute of Technology, 30332-0100 Atlanta, GA;(2) Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 30332-0100 Atlanta, GA;(3) Non-Invasive Cardiology Laboratory, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA |
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Abstract: | Mitral regurgitation results from the incomplete closure of the mitral valve, and the noninvasive diagnosis of this disease
remains an important clinical goal. In this study, steady flow computer simulations were used to evaluate flow convergence
method for flow rate estimation. The hemispheric and hemielliptic formulae were compared for accuracy in the presence of complicating
factors such, as ventricular confinement, orifice shape, and aortic outflow. Results showed that in the absence of aortic
outflow and ventricular confinement, there was a plateau zone where the hemispheric formula approximated the true flow rate,
independent of orifice shape. However, in the presence of complicating factors such as aortic outflow and ventricular confinement,
there was no clear zone where the hemispheric formula could be applied. The hemielliptic formula, however, worked in, all
cases, regardless of chamber size or magnitude of aortic outflow. Therefore, application of the hemielliptic formula shold
be considered in future clinical studies. |
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Keywords: | Mitral regurgitation Flow convergence method Heart valve Valvular regurgitation |
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