2012-2014年苏南地区育龄妇女人类微小病毒B19感染状况调查

目的 分析苏南地区育龄妇女微小病毒B19感染的状况,为本区妇幼保健提供基础数据。 方法 采用酶联免疫检测法(ELISA)检测2012-2014年苏南地区育龄妇女血清中特异性的IgM抗体。 结果 8 927例育龄妇女的微小病毒B19 IgM抗体阳性率为13.83%,近三年差异无统计学意义(χ²=0.35,P>0.05);不良妊娠结局组、正常妊娠组和婚检组感染率分别为16.37%、12.59%和13.39%,差异有统计学意义(χ²=16.76,P<0.05);感染组与非感染组不良妊娠结局发生率差异有统计学意义(χ²=38.71,P<0.05)。 结论 妊娠期HPVB19感染可引起不良妊娠结局。2012-2014年苏南地区育龄妇女感染率并不低,相关的妇幼保健单位应加强微小病毒B19的感染监测,开展全面检查,提高人口素质。

Human parvovirus B19 infection among pregnant women in the south area of Jiangsu, 2012-2014

Objective To analyze the status of human parvovirus (HPV) B19 infection in pregnant women in the south area of Jiangsu so as to provide basic data for maternal and child health care in this area. Methods Enzyme linked immunosorbent assay was used to detect specific IgM antibody in the sera of pregnant women in the south area of Jiangsu in 2012-2014. Results The positive rate of HPV B19 IgM antibody in 8,927 pregnant women was 13.83%, and no statistically significant difference was found among the 3 years (χ²=0.35, P>0.05). The infection rates of adverse pregnancy outcome group, normal pregnancy group and premarital checkup group were 16.37%, 12.59% and 13.39% respectively, with statistically significant differences (χ²=16.76, P<0.05). There were statistically significant differences in the incidence rate of adverse pregnancy outcome between the infection group and the non-infected group (χ²=38.71, P<0.05). Conclusions HPV B19 infection in pregnancy can cause adverse pregnancy outcomes. The infection rate of HPV B19 in pregnant women in the south area of Jiangsu in 2012-2014 is not low, and the related maternal and child health care units should strengthen the monitoring of HPV B19 infection and conduct a comprehensive examination so as to improve the quality of the population.