| 多药耐药相关蛋白2:在肠道药物处置中的重要作用 |
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| 引用本文： | 孙进,赵焰平,郝秀华,何仲贵. 多药耐药相关蛋白2:在肠道药物处置中的重要作用[J]. 中国新药与临床杂志, 2006, 25(10): 792-797 |
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| 作者姓名： | 孙进 赵焰平 郝秀华 何仲贵 |
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| 作者单位： | 1. 沈阳药科大学药学院生物药剂学研究室,辽宁,沈阳,110016
2. 吉林大学药学院,吉林长春,130021 |
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| 摘 要： | 多药耐药相关蛋白2(MRP2)是ATP结合盒转运蛋白超家族成员之一,是一种ATP依赖性有机阴离子转运蛋白。鉴于其广泛的底物专属性,MRP2在肠道药物处置中发挥着重要作用,包括肠吸收、肠分泌以及与肠道药物Ⅱ相代谢酶如谷胱甘肽-S-转移酶、UDP-葡萄糖醛酸转移酶及硫酸转移酶等的协同作用。此外,MRP2还影响着中药成分的肠吸收过程。
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| 关 键 词： | 多药耐药相关蛋白质类 肠吸收 药动学 药物外排 药物代谢 |
| 文章编号： | 1007-7669（2006）10-0792-06 |
| 收稿时间： | 2005-12-21 |
| 修稿时间： | 2005-12-212006-07-24 |
Multidrug resistance-associated protein 2: key role in intestinal drug disposition |
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| SUN Jin,ZHAO Yan-ping,HAO Xiu-hua,HE Zhong-gui. Multidrug resistance-associated protein 2: key role in intestinal drug disposition[J]. Chinese Journal of New Drugs and Clinical Remedies, 2006, 25(10): 792-797 |
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| Authors: | SUN Jin ZHAO Yan-ping HAO Xiu-hua HE Zhong-gui |
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| Affiliation: | 1.Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang LIAONING 110016, China; 2. School of Pharmacy, Jilin University, Changchun JILIN130021, China |
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| Abstract: | The multidrug resistance associated proteins 2 (MRP2) is a member of ATP-dependent organic anion transporters and ATP binding cassette transporters. With extensive substrate specificity, MRP2 plays a key role in intestinal drug disposition including absorption, secretion and in synergism withⅡphase metabolic enzymes (glutathione-S-transferase, UDP-glucuronyltransferase and sulfotransferase). In addition, MRP2 also influences the complicated absorption process of the traditional Chinese medicine, in particular for flavonoids. |
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| Keywords: | multidrug resistance-associated proteins intestinal absorption pharmacokinetics drug elflux drug metabolism |
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