GP-2在急性胰腺炎诊断中的临床价值

目的对血清GP-2(glycoprotein2)浓度在急性胰腺炎中的诊断价值进行研究。方法通过临床症状、血清酶学、影像学和病理学诊断的48例急性胰腺炎患者分为重症急性胰腺炎(n=28)和轻症急性胰腺炎(n=20)两组,另选择20例非胰腺炎腹痛患者作为对照组,测定他们血清中的GP-2浓度,并和他们的血清酶学结果进行比较。结果GP-2诊断急性胰腺炎的特异性为100%,高于淀粉酶(83.3%)和脂肪酶(89.6%);淀粉酶和脂肪酶水平分别在入院后的第3及第4天降至正常值上限的3倍以下,而在观察的第6天,GP-2水平仍然维持在诊断标准的5倍以上;同时在轻症急性胰腺炎和重症急性胰腺炎患者,GP-2平均水平分别为4.71U和11.30U,后者明显高于前者(P<0.05)。结论GP-2对急性胰腺炎的早期诊断特异性高,持续时间长,同时对病情的判断有一定的帮助,因此有相当的I临床应用价值。

Clinical diagnostic value of glycoprotein 2 in acute pancreatitis

Objective To evaluate the significance of GP-2 in clinical diagnosis of acute pancreatitis. Methods Serum concentration of GP-2 was measured in 20 patients with mild acute pancreatitis (MAP), 28 patients with severe acute pancreatitis (SAP) and 20 patients without pancreatic disease consecutively for 6 days. Results The specificity of GP-2, serum amylase and serum lipase to the diagnosis of acute pancreatitis was 100%, 83. 3% and 89. 6%, respectively. At 6 d of observation, GP-2 level was 5 times as high as the upper limit of the normal range. Compared to MAP, serum GP-2 level was higher in SAP(P < 0. 05). Conclusions Compared with pancreatic enzymes, GP-2 has higher specificity in the diagnosis of acute pancreatitis and lasts for a longer time. Moreover, it can help estimate the prognosis of AP.