| 万寿菊提取物改善老龄大鼠抗氧化功能的研究 |
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| 引用本文： | 裴凌鹏,惠伯棣,董福慧.万寿菊提取物改善老龄大鼠抗氧化功能的研究[J].中国老年学杂志,2007,27(9):814-816. |
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| 作者姓名： | 裴凌鹏 惠伯棣 董福慧 |
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| 作者单位： | 1. 中国中医科学院骨伤科研究所,北京,100700
2. 北京联合大学应用文理学院 |
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| 基金项目： | 国家自然科学基金;北京市自然科学基金 |
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| 摘 要： | 目的研究万寿菊提取物（叶黄素）对D-半乳糖致衰老大鼠抗氧化能力的影响。方法用D-半乳糖注射Wistar雄性大鼠5个月，建立衰老模型。对衰老模型组、叶黄素组血清丙二醛（MDA）含量、肝脏匀浆MDA含量和血液超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH．Px）活性进行测定及比较。结果叶黄素组血清MDA含量和肝脏匀浆MDA含量均比衰老模型组有所降低，而血液SOD、GSH—Px酶活性有所升高（P〈0．01）。结论摄入适量万寿菊提取物可以有效地增强大鼠机体抗氧化能力，从而延缓D-半乳糖诱发的大鼠衰老。
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| 关 键 词： | 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 万寿菊 |
| 文章编号： | 1005-9202（2007）09-0814-03 |
| 收稿时间： | 2006-06-08 |
| 修稿时间： | 2006-08-31 |
Effect of Tagetes erecta L. 's extraction on antioxidative function in aged rats |
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| PEI Ling-Peng,HUI Bo-Di,DONG Fu-Hui.Effect of Tagetes erecta L. ''''s extraction on antioxidative function in aged rats[J].Chinese Journal of Gerontology,2007,27(9):814-816. |
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| Authors: | PEI Ling-Peng HUI Bo-Di DONG Fu-Hui |
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| Institution: | Department of Bone Traumatology, China Academy of Chinese Traditional Medicine Science, Beijing 100700, China |
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| Abstract: | Objective To study the effect of extraction of Tagetes erecta L. on the antioxidative function of D-galactose (D-gal)induced aged rat.Methods Wistar rats had been given D-gal injections for 5 months to make aging model.They were randomly divided in model group,low-dose lutein group,middle-dose lutein group and high-dose lutein group.Then the content of serum MDA,liver MDA and the activity of SOD and GSH-Px were tested and compared with each group.Results Compared with model group,the content of serum MDA,liver MDA in the lutein group were significantly decreased (P<0.01).However the activity of SOD and GSH-Px was significantly raised(P<0.01).Conclusions Extraction of Tagetes erecta L. can increase antioxidative function of rat and postpone consenescence induced by D-gal. |
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| Keywords: | Malondialdehyde (MDA) Superoxide dismutase (SOD) Glutathione peroxidase (GSH-Px) Tagetes erecta L |
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