糖尿病患者血脂水平与动脉粥样硬化的相关性分析

目的：探讨不同年龄段2型糖尿病(T2DM)患者的血脂水平与动脉粥样硬化(AS)的关系。方法177例T2DM患者分为单纯T2DM组和T2DM+AS组,对照组为177例健康中老年人,各组分为两个年龄亚组(41~65岁组和66~85岁组)。检测各组患者血脂水平,彩超测定颈动脉内-中膜厚度(IMT),分析血脂水平、AS和IMT程度的相关性。结果 T2DM+AS组与单纯T2DM组相比,血脂水平(总胆固醇和低密度脂蛋白)均明显升高(P<0．05)；而单纯T2DM组与对照组差异无统计学意义(P>0．05)。 T2DM+AS组IMT明显高于单纯T2DM组及空白对照组(P<0．05)。在66~85岁组中,T2DM+AS与单纯T2DM患者的血脂水平差异有统计学意义(P<0．05),并且血脂水平与IMT呈正相关。结论 T2DM患者AS发生率与血脂水平呈正相关,且随着年龄的增加,相关性愈发明显。

Analysis of correlation between different age diabetes clinical serum lipid levels and atheroma

Objective To explore the relationship between clinical biochemical blood lipid index in elder patients with type 2 diabe-tes and atherosclerosis. Methods One hundred and seventy-seven elder patients with type 2 diabetes mellitus were divided into simple diabe-tes group (T2DM group) and type 2 diabetes with carotid atherosclerosis group (T2DM +AS group), and 177 healthy elder patients within the same age range were included as the control group. The clinical biochemical indicators of blood lipid index were measured and the intima-media thickness ( IMT) was measured by Colour Doppler Ultrasound. All the groups were divided into 2 age subgroups:41~65 years old group and 66~85 years old group. The relationships between the levels of serum lipids and atherosclerosis as well as IMT in different age groups were analyzed. Results In comparison with simple T2DM group, both the 2 serum lipid levels (total cholesterol and LDL) in T2DM+AS group were significantly higher(P<0. 05). However, there was no significant difference between T2DM group and control group(P>0. 05). The thickness of IMT in T2DM+AS was significantly higher than that in T2DM group and control group. The serum lipid level of eld-erly patients(66~85 years) was much more higher(P<0. 05). Serum lipid levels of T2DM patients were positively related to the thickness of IMT. Conclusion Serum lipid levels of T2DM patients were positively related to the incidence of AS. And as the increase of age,the tendency is more and more obviously.