| 共聚维酮辅助馨月舒喷雾干燥及其对粉体学性质的影响 |
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| 引用本文： | 蒋艳荣,张振海,丁冬梅,严红梅,胡绍英,贾晓斌. 共聚维酮辅助馨月舒喷雾干燥及其对粉体学性质的影响[J]. 中国中药杂志, 2013, 38(23): 4067-4070 |
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| 作者姓名： | 蒋艳荣 张振海 丁冬梅 严红梅 胡绍英 贾晓斌 |
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| 作者单位： | 江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;南京中医药大学, 江苏 南京 210046;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;南京中医药大学, 江苏 南京 210046 |
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| 基金项目： | 江苏省社会发展科技支撑计划项目（BE2010756）；江苏省中医药科技项目（LZ11065） |
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| 摘 要： | 研究共聚维酮（PVP-S630）在馨月舒提取液喷雾干燥过程中的应用特性及其对粉体学及体外释药行为等药剂学性质的影响。通过在馨月舒提取液中添加PVP-S630进行共喷雾干燥研究，考察PVP-S630不同用量对解决喷雾干燥黏壁效果的影响，同时考察馨月舒共喷雾干燥粉体的粉体学性质和有效成分金丝桃苷的体外溶出行为。结果表明PVP-S630抗黏壁效果显著，共喷雾干燥粉体粒径无明显变化，流动性提高，吸湿性改善，金丝桃苷体外溶出度显著提高。PVP-S630在中药喷雾干燥粉体中的应用值得进一步研究。
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| 关 键 词： | PVP-S630 喷雾干燥 流动性 体外溶出度 |
| 收稿时间： | 2013-04-15 |
Study on Xinyueshu spray drying assisted with copovidone and its effect on powder property |
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| JIANG Yan-rong,ZHANG Zhen-hai,DING Dong-mei,YAN Hong-mei,HU Shao-ying and JIA Xiao-bin. Study on Xinyueshu spray drying assisted with copovidone and its effect on powder property[J]. China Journal of Chinese Materia Medica, 2013, 38(23): 4067-4070 |
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| Authors: | JIANG Yan-rong ZHANG Zhen-hai DING Dong-mei YAN Hong-mei HU Shao-ying JIA Xiao-bin |
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| Affiliation: | Key Laboratory of New Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210046, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210046, China |
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| Abstract: | To study the application characteristics of copovidone(PVP-S630) in Xinyueshu extracts during the spray drying process, and its effect on such pharmaceutical properties as micromeritics and drug release behavior. PVP-S630 was added into Xinyueshu extracts to study on the spray drying, the effect of different dosages of PVP-S630 against the wall sticking effect of the spray drying, as well as the power property of Xinyueshu spray drying power and the dissolution in vitro behavior of the effective component of hyperoside. The results showed that PVP-S630 revealed a significant anti-wall sticking effect, with no notable change in the grain size of the spray drying power, increase in the fluidity, improvement in the moisture absorption and remarkable rise in the dissolution in vitro behavior of hyperoside. It was worth further studying the application of PVP-S630 in spray drying power of traditional Chinese medicine. |
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| Keywords: | PVP-S630 spray drying fluidity dissolution in vitro |
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