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Corticotropin-releasing factor potentiates acoustic startle in rats: Blockade by chlordiazepoxide |
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| Authors: | Swerdlow N R Geyer M A Vale W W Koob G F |
| Institution: | (1) Department of Neuroscience, Medical Scientist Training Program, University of California, 92093 San Diego, CA, USA;(2) Department of Psychiatry, University of California, 92093 San Diego, CA, USA;(3) The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 92138 La Jolla, CA, USA;(4) Division of Preclinical Neuroscience and Endocrinology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037 La Jolla, CA, USA |
| Abstract: | A series of experiments was performed to investigate the effects of corticotropin-releasing factor (CRF) on the amplitude of the acoustic startle response (ASR) in rats. Intracerebroventricular (ICV) administration of 1  g rat CRF significantly potentiated acoustic startle amplitude; these effects were reversed in a dose-dependent manner by pretreatment with the benzodiazepine chlordiazepoxide (CDP). Doses of CDP that anatgonized CRF-potentiated ASR did not lower startle baseline or antagonize amphetamine-or strychnine-potentiated ASR. These results suggest that CRF has  anxiogenic properties and may serve as a neuroendocrine modulator of stress-enhanced behaviors. |
| Keywords: | Corticotropin-releasing factor Startle Chlordiazepoxide Anxiety Strychnine Amphetamine |
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