肺炎衣原体感染与慢性阻塞性肺疾病严重程度和急性发作的相关性

目的探讨肺炎衣原体感染与慢性阻塞性肺疾病（COPD）严重程度和急性发作的相关性。方法选择20例正常对照者和120例COPD稳定期患者，采用巢式聚合酶链反应（nPCR）检测痰中的肺炎衣原体DNA，随访观察nPCR阳性和阴性患者在1年中的急性发作次数。结果COPD组的肺炎衣原体nPCR阳性率明显高于正常对照组；肺功能受损严重者的肺炎衣原体nPCR阳性率显著升高；nPCR阳性患者的急性发作频率明显高于阴性组。结论肺炎衣原体慢性定植与慢性阻塞性肺疾病急性发作相关。

Correlation between chlamydia pneumonia infection and severity and acute attack of chronic obstructive pulmonary disease

Objective To explore the correlation between the chlamydia pneumonia infection and the severity degree and acute exacerbations of chronic obstructive pulmonary disease (COPD).Methods Chlamydia pneumonia DNA in 20 normal controls and 120 cases of stable COPD were detected by nested-PCR in sputum.Follow-up was made to observe the frequency of acute exacerbation of COPD within a year in the nPCR positive and negative patients.Results nPCR positive rate in COPD group was obviously higher than that in control group,which increased significantly in the patients with badly damaged pulmonary function.The frequency of acute exacerbation in nPCR positive patients was higher than that of the opposite group.Conclusion Chlamydia chronic plantation is related to the acute exacerbation of COPD.