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Capillary electrophoresis as a versatile tool for the bioanalysis of drugs--a review |
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| Authors: | Boone C M Waterval J C Lingeman H Ensing K Underberg W J |
| Affiliation: | a Department of Analytical Chemistry and Toxicology, University Center for Pharmacy, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands b Department of Pharmaceutical Analysis, University of Utrecht, Sorbonnelaan 16, 3508 TB, Utrecht, The Netherlands c Department of Analytical Chemistry and Applied Spectroscopy, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands |
| Abstract: | This review article presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The principles of capillary electrophoresis and its various separation and detection modes are briefly discussed. Sample pretreatment methods which have been used for clean-up and concentration are discussed. Finally, an extensive overview of bioanalytical applications is presented. The bioanalyses of more than 200 drugs have been summarised, including the applied sample pretreatment methods and the achieved detection limits. |
| Keywords: | Capillary electrophoresis Micellar electrokinetic chromatography Bioanalysis Drugs Detection limit Review |
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