| IL-25与免疫相关疾病关系的研究进展 |
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| 引用本文： | 王楷文,许化溪.IL-25与免疫相关疾病关系的研究进展[J].国际免疫学杂志,2010,33(2):136-140. |
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| 作者姓名： | 王楷文 许化溪 |
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| 作者单位： | 江苏大学基础医学与医学技术学院,镇江,212013 |
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| 摘 要： | IL-25又称为IL-17E，是细胞因子IL-17家族的成员之一，主要由活化的Th细胞和肥大细胞所分泌。与其他家族成员不同，IL-25能够诱导Th2型细胞因子如IL-4、IL-5和IL-13的产生，介导Th2类免疫应答，还能够影响Th17细胞的分化并调节自身免疫性疾病的发生发展。总之，IL-25在多种免疫性疾病的发生发展中都发挥着重要的作用。
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| 关 键 词： | IL-25 IL-17 Th2细胞 超敏反应 自身免疫性疾病 |
Advances on the correlation between interleukin-25 and immunological diseases |
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| WANG Kai-wen,XU Hua-xi.Advances on the correlation between interleukin-25 and immunological diseases[J].International Journal of Immunology,2010,33(2):136-140. |
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| Authors: | WANG Kai-wen XU Hua-xi |
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| Institution: | .( Department of Immunology, University of Jiangsu, Zhenjiang 212013, China ) |
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| Abstract: | Interleukin-25(IL-17E)is a member of the recently emerged cytokine family(IL-17s),which is expressed in Th2-polarized T-cels and bone marrow-derived mast ceHs.However,unlike the other members of this family,IL-25 is capable of inducing Th2-associated cytokines(IL-4,IL-5,and IL-13).IL-25 is a proinflammatory cytokine favoring Th2-type immune,also regulates the development of autoimmune intl ammation mediated by IL-17-producing T cells.Taken together,IL-25 plays important roles in the pathogenesis of immunological diseases. |
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| Keywords: | IL-25 IL-17 |
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