蒽环类药物累积剂量与血清心肌肌钙蛋白T水平关系的研究

 目的　研究蒽环类药物累积剂量与血清心肌肌钙蛋白T（cTnT）水平的关系。方法　回顾性分析2004年1月至2009年1月应用蒽环类药物化疗的88例急性白血病患者cTnT水平及其蒽环类药物累积剂量，以某一累积剂量水平分组计算各组cTnT升高的发生率。结果　蒽环类药物累积剂量＜200 mg／m2组51例，1例 cTnT水平升高，蒽环类药物累积剂量≥200 mg／m2组37例，　8例cTnT水平升高，两组cTnT升高的发生率差异有统计学意义（P＜0.05）。结论　蒽环类药物达到一定剂量时，cTnT升高发生率明显升高。

Clinical study on correlation of cTnT level with accumulated dose of anthracycline

Objective To study the relationship of accumulated dose of anthracycline(ANTH) with the cTnT level in acute leukemia patients. Methods The cTnT levels and the accumulated dose of anthracycline (ANTH) of 88 acute leukemia patients who were treated with anthracycline in our hospital from 2004-2009 who were treated with anthracycline. All the patients were divided into two groups according to a certain cTnT level,and the each incidence of elevated cTnT was obtained. Results 8 of 37 patients who received ≥200 mg/m2 of ANTH versus 1 of 51 patients who received <200 mg/m2 of ANTH had a higher incidence of elevated cTnT (P <0.05). Conclusion Incidence of elevated cTnT increases when the ANTH reaches the certain dose.