血管紧张素转换酶抑制剂治疗高血压的咳嗽发生率和停药率

目的:研究血管紧张素转换酶抑制剂(ACE抑制剂)治疗高血压的咳嗽发生率和停药率。方法:对心血管内科门诊应用福辛普利、西拉普利、苯那普利的高血压病人进行问卷调查、统计分析。结果:应用上述三种药物者共1038例,咳嗽总发生率为36.9％,因咳嗽而停药率为41.8％,三药之间比较无差别(P值均>0.05)。不同性别的咳嗽发生率和停药率没有差别,但是不同年龄咳嗽发生率(≤60岁41.7％,>60岁31.6％,P=0.0009)和停药率(≤60岁64.4％,>60岁35.6％,P=0.00001)均有显著差别。结论:中国人服用ACE抑制剂治疗高血压的咳嗽发生率和停药率较高,不同ACE抑制剂之间无差别。老年人咳嗽发生率和停药率相对较低。

Prevalence of Cough and Withdrawal of Angiotensin Converting Enzyme Inhibitors In Treatment of Hypertension

Objective: To study the prevalence of cough and withdrawal of angiotensin converting enzyme inhibitors (ACEI) in treatment of hypertension. Methods: Questionnaire study of hypertension out - patients treatment with cilazapril, fosinopril and be-nazepril. Results: Total 1 038 cases were studied. The prevalence of cough was 36.9% .withdrawal was 41.8% . No difference a-mong these three ACEI (P > 0.05). The prevalence of cough and withdrawal were no difference in male and female, but were different with ages (cough: ^60yrs41.7% > 60yrs 35.6%, P = 0.000 9; withdrawal: <60yrs 64.4% >60yrs 35.6% P = 0.000 01). Conclusion: The prevalence of cough and withdrawal of ACEI in treatment of hypertension were high in Chinese , and no difference a-mong different ACEI. Old patients had lower cough and withdrawal rate than young patients.