| Her-2/neu基因与放射敏感性 |
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| 引用本文： | 李炯雁,郭小毛. Her-2/neu基因与放射敏感性[J]. 中国癌症杂志, 2008, 18(11) |
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| 作者姓名： | 李炯雁 郭小毛 |
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| 作者单位： | 复旦大学附属肿瘤医院放射治疗科,复旦大学上海医学院肿瘤学系,上海,200032 |
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| 摘 要： | Her-2受体己成为一些恶性肿瘤的重要生物靶标,在恶性肿瘤的生物行为中发挥重要作用.其过度表达可能与肿瘤的放射抗拒密切相关,因此抗Her-2受体抗体可能具有放射增敏作用.抗Her-2受体抗体结合放射治疗可能为肿瘤治疗开辟新的道路.
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| 关 键 词： | 抗Her-2抗体 放射治疗 恶性肿瘤 |
Her-2/neu gene and radiosensitivity |
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| LI Jiong-yan,GUO Xiao-mao. Her-2/neu gene and radiosensitivity[J]. China Oncology, 2008, 18(11) |
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| Authors: | LI Jiong-yan GUO Xiao-mao |
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| Affiliation: | LI Jiong-yan GUO Xiao-mao (Department of Radiation Oncology,Cancer Hospital,Fudan University,Department of Oncology,Shanghai Medical College,Shanghai 200032,China) |
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| Abstract: | Her-2 receptor has already been identified as one of the most important biological markers of some malignant tumors,and also plays an important role in the biological behavior of those tumor cells.The over-expression of Her-2 receptor is associated with radioresistance of various tumor cells,and thus an antibody to Her-2/neu receptor can probably function as a radiosensitizer.In this review,we summarized some advances in the molecular mechanism and clinical aspects of the relationship between Her-2 and cell... |
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| Keywords: | Her-2/neu |
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