The Role of Diastolic Pump Flow in Centrifugal Blood Pump Hemodynamics |
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Authors: | Takehide  Akimoto,Kenneth N.  Litwak,Kenji  Yamazaki,Philip  Litwak,Shin-ichiro  Kihara,&dagger Osamu  Tagusari,&Dagger Shun-ich  Yamazaki,Marina V.  Kameneva,Mary J.  Watach,§ Mitsuo  Umezu,Jun  Tomioka,Robert L.  Kormos,&dagger Hitoshi  Koyanagi, Bartley P.  Griffith |
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Affiliation: | Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A. |
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Abstract: | We tried to verify the hypothesis that increases in pump flow during diastole are matched by decreases in left ventricular (LV) output during systole. A calf (80 kg) was implanted with an implantable centrifugal blood pump (EVAHEART, SunMedical Technology Research Corp., Nagano, Japan) with left ventricle to aorta (LV-Ao) bypass, and parameters were recorded at different pump speeds under general anesthesia. Pump inflow and outflow pressure, arterial pressure, systemic and pulmonary blood flow, and electrocardiogram (ECG) were recorded on the computer every 5 ms. All parameters were separated into systolic and diastolic components and analyzed. The pulmonary flow was the same as the systemic flow during the study (p > 0.1). Systemic flow consisted of pump flow and LV output through the aortic valve. The ratio of systolic pump flow to pulmonary flow (51.3%) did not change significantly at variable pump speeds (p > 0.1). The other portions of the systemic flow were shared by the left ventricular output and the pump flow during diastole. When pump flow increased during diastole, there was a corresponding decrease in the LV output (Y = -1.068X + 51.462; R(insert)(2) = 0.9501). These show that pump diastolic flow may regulate expansion of the left ventricle in diastole. |
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Keywords: | Centrifugal blood pump Diastolic pump flow Hemodynamics Left ventricular assist device Real-time analysis |
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