儿童多发性肌炎与皮肌炎17例临床分析

目的探讨儿童皮肌炎/多发性肌炎(JDM/PM)的临床特点、辅助检查与治疗。方法回顾性分析本院1994年1月~2004年12月诊治的17例JDM/JPM。结果主要有肌无力、肌痛或肌压痛、关节疼痛和发热等;存在肺、心脏、胃肠道、肾损害,未见伴恶性肿瘤和钙质沉着者;LDH、HBDH、AST、CPK、α2、γ球蛋白升高,HB降低,ESR增快,RF阳性;EMG示肌源性改变,肌活检异常。结论本病以肌肉症状最多见,肌酶升高显著,以心、肺损害多见,经激素治疗均有所缓解,预后较好。

Clinical Analysis of 17 Patients with Juvenile Dermatomyositis / Polymyositis

Objective To study the clinical characteristics,auxiliary examination and treatment of juvenile dermatomyositis/ polymyositis (JDM/PM).Methods 17 hospitalized cases suffering from JDM/PM in our hospital from January,1994 to December,2004 were studied retrospectively.Results The patients with JDM/PM manifested muscle weakness,myalgia,arthralgia and fever. Although lungs,heart,gastrointestinal tract,and kidney were involved,there was no complicated with malignancy and calcinosis.In abnormal laboratory data,there were LDH,HBDH,AST,CPK,alpha-2 and gamma globulins,HB,ESR and RF.EMG revealed myogenic damage and there was abnormal muscle biopsy.Conclusion The muscle symptom is the commonest in the JDM/PM patients,there were significant elevation of serum muscle enzymes.The pulmonary and cardiac involvements are predominant in the cases.They were relieved after treated with glucocorticoid and the prognosis is good.