异甘草酸镁及甘草酸二铵短期治疗对慢性乙肝患者血清转氨酶水平影响的比较

目的 通过异甘草酸镁与甘草酸二铵的对比，观察异甘草酸镁短期治疗慢性乙肝的疗效。方法将68例慢性乙肝患者随机分为治疗组（35例）和对照组（33例），在同样常规综合治疗的基础上，治疗组加用异甘草酸镁150mg，1次／d，静脉滴注，对照组加用甘草酸二铵150mg，1次／d，静脉滴注。观察两组治疗前后患者血清中丙氨酸氨基转移酶（ALT）与天冬氨酸氨基转移酶（AST）指标的变化，以及出现的不良反应。结果两组治疗后血清ALT与AST均较治疗前显著下降（P〈0．05），与对照组相比，治疗组各指标下降显著（P〈0．05）。结论异甘草酸镁短期治疗慢性乙肝不仅疗效好，且不良反应少。

Comparative study on the therapeutic effects of short-term use of magnesium isoglycyrrhizinate versus Diammonium glycyrrhizinate on patients of chronic hepatitis B

Objective To evaluate the therapeutic effect of magnesium isoglycyrrhizinate on patients of chronic hepatitis B in short -term versus diammonium glycyrrhizinate. Methods 68 chronic hepatitis B patients were divided into two groups randomly. In treatment group（35 cases）, 150mg magnesium isoglycyrrhizinate were given intravenous drip per day, on the other hand, control group（33 cases） were given diammonium glycyrrhizinate with same dosage each day. Beside this, all patients were treated with regular combined therapy. Symptoms, signs, hepatic function and adverse reactions were observed in both groups. Results The amelioration in symptoms, signs and hepatic function in treatment group were better than control group with significant difference（ P 〈 0. 05 ）. Conclusion Magnesium isoglyctrrhizinate is better than diammonium glyctrrhizinate in therapeutic effects and adverse reactions on chronic hepatitis B patients.