| 糖皮质激素受体基因G1666T多态性与原发性高血压的相关性 |
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| 引用本文： | 迟兰芹,张晨,宋明军,孙风翠. 糖皮质激素受体基因G1666T多态性与原发性高血压的相关性[J]. 基础医学与临床, 2006, 26(1): 70-73 |
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| 作者姓名： | 迟兰芹 张晨 宋明军 孙风翠 |
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| 作者单位： | 烟台市莱阳中心医院,神经内科,山东,莱阳,265200;青岛大学,医学院,附属医院神经内科,山东,青岛,266003 |
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| 摘 要： | 目的探讨糖皮质激素受体基因第4内含子基因G1666T多态性与原发性高血压(essential hypertension,EH)的关系。方法用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析71例正常人及48例原发性高血压患者中GR基因第4内含子变异的多态性分布情况。结果从整体来讲,不分性别,GR基因第4内含子的变异在EH与对照组之间,其基因型频率、等位基因的频率无显著性差异。而在女性,与对照组(0.46)比较,EH(0.64)等位基因G的频率明显增高(P<0.05)。结论等位基因G的频率增高可能是原发性高血压的易感基因标志。
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| 关 键 词： | 高血压 糖皮质激素受体 基因多态性 聚合酶链反应 限制性片段长度多态性 |
| 文章编号： | 1001-6325(2006)01-0070-04 |
| 收稿时间： | 2004-08-12 |
| 修稿时间： | 2005-03-29 |
Association between glucocorticoid receptor gene G1666T polymorphism and essential hypertension |
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| CHI Lan-qin,ZHANG Chen,SONG Ming-jun,SUN Feng-cui. Association between glucocorticoid receptor gene G1666T polymorphism and essential hypertension[J]. Basic Medical Sciences and Clinics, 2006, 26(1): 70-73 |
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| Authors: | CHI Lan-qin ZHANG Chen SONG Ming-jun SUN Feng-cui |
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| Affiliation: | 1. Department of Neurology, Laiyang Central Hospital, Yantal 265200; 2. Department of Neurology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China |
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| Abstract: | Objective To identify the association between human glucocorticoid receptor gene G166T polymorphism and essential hypertension(EH).Methods DNA samples from 71 normotensive cases and 48 EH cases were analyzed by a polymerase chain reaction(PCR) for restriction fragment length polymorphism(RFLP) to determine the intron 4 variant of human glucocorticoid receptor gene.Results No association was observed between EH group and control group.However,in females,a little association was observed between the EH group and control group.Frequencies of allele G were 0.64 in EH group and 0.46 in control group.Conclusion The G allele may be a predisposing gene marker,HGR gene intron 4 polymorphism contributes to the development of EH in females. |
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| Keywords: | hypertension glucocorticoid receptor gene polymorphism PCR-RFLP |
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