Serum interleukin-6 and survivin levels predict clinical response to etanercept treatment in patients with established rheumatoid arthritis |
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Authors: | Rui Shi Muzhi Chen Bahaerguli Litifu |
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Institution: | Department of Rheumatology and Immunology, Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, Xinjiang, China |
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Abstract: | Objectives: To investigate the correlation of nine potential biomarkers with clinical response to etanercept (ETN) therapy in establish rheumatoid arthritis (RA) patients.Methods: Seventy-three patients with established RA were enrolled in the prospective cohort study. Sixty-nine of 73 cases were included into final analysis for response after 24-week ETN therapy. Serum expression of nine studied proteins was measured by enzyme-linked immunosorbent assay (ELISA). Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-17A, IL-21, IL-34, RANKL, survivin, and COMP were selected as candidate biomarkers.Results: Serum IL-6 level was increased in responders than in nonresponders at baseline, p?=?.034; to the contrary, serum survivin level was decreased in responders, p?=?.009. Receiver operating characteristic (ROC) curve illuminated the combination of IL-6 and survivin expressions could predict clinical response with a high AUC 0.875, 95% CI: 0.771–0.976. Furthermore, we found the combination of IL-6 high expression and survivin low expression increased the responding possibility to nearly 20-fold (OR 19.687, 95% CI: 4.087–94.839, p?<?.001) compared to IL-6 low or survivin high expression by univariate analysis. However, only survivin low expression (p?=?.002) and CRP (p?=?.014) high expression were independent predictive factors for achieving clinical response, while IL-6 lack independent predictive value (p?=?.267).Conclusions: Comprehensive measurement of IL-6 and survivin in serum could be served as a convincing biomarker for clinical response in ETN-treated patients with established RA. |
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Keywords: | Etanercept interleukin-6 predict response survivin |
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