Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease |
| |
| Authors: | Tomohiro Handa Hajime Yoshifuji Yuzo Kodama Hiroshi Yamamoto Seijiro Minamoto |
| |
| Affiliation: | 1. Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan;2. Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;3. Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;4. First Department of Internal Medicine, Shinshu University School of Medicine, Nagano, Japan;5. Department of Medicine for Allergic Diseases, Osaka Habikino Medical Center, Osaka, Japan |
| |
| Abstract: | Objectives: Serum soluble interleukin-2 (IL-2) receptor (sIL-2R) might reflect disease activity in immunoglobulin G4-related disease (IgG4-RD). We aimed to elucidate the clinical significance of blood markers, including sIL-2R, in patients with IgG4-RD.Methods: We enrolled 59 patients with IgG4-RD and investigated the association between blood markers (white blood cells, C-reactive protein, sIL-2R, IgG, IgG4, IgE, total hemolytic complement), and clinical indices.Results: At baseline, serum sIL-2R (Rs?=?0.532, p?p?Conclusion: The serum sIL-2R level is a potential biomarker for IgG4-RD that may reflect the number of involved organs and may predict patients requiring glucocorticoid treatment. |
| |
| Keywords: | Biomarker IgG4-related disease soluble IL-2 receptor |
|
|
