电刺激小脑顶核对急性脑梗死患者血浆一氧化氮和内皮素-1浓度的影响及其意义

目的:应用电刺激脑梗死患者小脑顶核的治疗方法,观察其神经病学评分及血浆一氧化氮、内皮素-1浓度变化情况,进一步探讨电刺激小脑顶核对脑梗死患者的神经保护作用机制.方法:将68例脑梗死患者随机分为电刺激治疗组(电刺激小脑顶核组)和常规药物组,另设40例高血压患者作为正常对照组.观察各组受试者治疗前后神经功能缺损评分及血浆一氧化氮、内皮素-1浓度的变化.结果:电刺激治疗组较常规药物组神经功能恢复更好(P<0.05);血浆内皮素-1、一氧化氮浓度也均较常规药物组下降更快(P均<0.05).结论:电刺激小脑顶核治疗,可促进脑梗死患者血浆内皮素-1、一氧化氮浓度下降,这可能与电刺激小脑顶核的神经保护作用有关.

Effects of electric stimulation at fastigial nucleus on plasma endothelin-1 and nitric oxide in patients with acute cerebral infarction

Objective: To observe the effect of electric stimulation at fastigial nucleus (FN) on neurological deficiency score, endothelinCD*21 (ETCD*21) and nitric oxide (NO) levels and to investigate its neuroprotective effects on patients with acute cerebral infarction (ACI). Methods: Sixty-eight patients with ACI were randomly divided into two groups: the electric stimulation treatment group (electric stimulation at FN) and conventional treatment group. Forty patients with hypertension were in the control group. The neural deficiency score, concentrations of plasma ETCD*21 and NO of patients in each group were observed. Results : Compared to the conventional treatment group, the improvement of neural function, the decrease of plasma ETCD*21 and NO were more significant in the electric stimulation treatment group before and after the treatment (all P<0.05). Conclusion: Electric stimulation at FN can decrease the plasma levels of ETCD*21 and NO in patients with ACI, that may play a role in the protection of ischemic neurons in patients with ACI.