| P16INK4a甲基化与宫颈癌的关系 |
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| 引用本文： | 宋艳亭,丁晓萍,何君.P16INK4a甲基化与宫颈癌的关系[J].职业与健康,2011,27(9):1044-1046. |
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| 作者姓名： | 宋艳亭 丁晓萍 何君 |
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| 作者单位： | 1. 泰山医学院,山东省泰安市,271016;第二炮兵总医院
2. 第二炮兵总医院 |
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| 摘 要： | P16INK4a基因是人们发现的第1个直接参与细胞周期调控的抑癌基因。P16IINK4a基因异常甲基化是宫颈癌发生过程中的早期事件,且随着病情发展甲基化率有增高的趋势。P16INK4a异常甲基化可作为一种新的肿瘤分子标记物用于宫颈癌的临床筛查及诊断中。
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| 关 键 词： | P16INK4a 甲基化 DNA 宫颈癌 CIN |
Relationship between P16INK4a Methylation and Cervical Cancer |
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| SONG Yan-ting,DING Xiao-ping,HE Jun.Relationship between P16INK4a Methylation and Cervical Cancer[J].Occupation and Health,2011,27(9):1044-1046. |
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| Authors: | SONG Yan-ting DING Xiao-ping HE Jun |
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| Institution: | SONG Yan-ting,DING Xiao-ping,HE Jun(Taishan Medical College,Shandong,271016,China) |
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| Abstract: | P16INK4a gene is the first known tumor suppressor gene involved in cell cycle regulation.The abnormal methylation of P16INK4a is an early event in the process of cervical cancer,and the methylation rate increases with the development of cervical cancer.The abnormal methylation of P16INK4a may be a new tumor marker in clinical screening and diagnosis of cervical cancer. |
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| Keywords: | P16INK4a Methylation DNA Cervieal Cancer CIN |
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