|
|||||
|
|
| 阻塞性睡眠呼吸暂停低通气综合征与氧化抗氧化相关性研究 | |
| 引用本文： | 高爱武,高淑磊,韩丽娟,平芬,李琪,田玉静.阻塞性睡眠呼吸暂停低通气综合征与氧化抗氧化相关性研究[J].职业与健康,2011,27(22):2521-2524. |
| 作者姓名： | 高爱武 高淑磊 韩丽娟 平芬 李琪 田玉静 |
| 作者单位： | 1. 河北省保定市第二医院呼吸科,071000 2. 保定市第四医院 3. 河北省人民医院 |
| 摘 要： | 目的观察阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea-hypopnea Syndrome,OSAHS)患者及OSAHS相关高血压(OSAHAHT)患者血清中氧化低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)及铜锌超氧化物歧化酶(copper-zinc superoxide dismutase,CuZnSOD)水平的变化。方法选择OSAHS及OSAHAHT患者各20例及健康对照组20例,应用酶联免疫吸附试验检测血清中ox-LDL水平,用黄嘌呤氧化酶法检测血清中CuZnSOD水平,并与睡眠监测指标进行相关分析。结果与对照组比较,OSAHS及OSAHAHT组患者血清中ox-LDL浓度升高,CuZnSOD浓度降低(P<0.01),差异有统计学意义(P<0.01)。OSAHS及OSAHAHT组患者血清中ox-LDL、CuZnSOD水平与反映睡眠呼吸暂停严重程度的指标有相关性(P<0.01)。结论 OSAHS及OSAHAHT患者血清中ox-LDL及CuZnSOD水平有变化,存在氧化应激,血清中ox-LDL及CuZnSOD水平可以反映OSAHS患者的病情严重程度。 |
| 关 键 词： | 阻塞性睡眠呼吸暂停低通气综合征 氧化低密度脂蛋白 铜锌超氧化物歧化酶 高血压 氧化抗氧化 |
Correlational Study of Oxidation, Antioxidation and Obstructive Sleep Apnea Hypopnea Syndrome |
|
| GAO Ai-wu,GAO Shu-lei,HAN Li-juan,PING Fen,LI Qi,TIAN Yu-jing.Correlational Study of Oxidation, Antioxidation and Obstructive Sleep Apnea Hypopnea Syndrome[J].Occupation and Health,2011,27(22):2521-2524. | |
| Authors: | GAO Ai-wu GAO Shu-lei HAN Li-juan PING Fen LI Qi TIAN Yu-jing |
| Institution: | GAO Ai-wu,GAO Shu-lei,HAN Li-juan,PING Fen,LI Qi,TIAN Yu-jing(Baoding Second Hospital,Hebei,071000,China) |
| Abstract: | Objective]To observe the changes of serum oxidized low density lipoprotein(ox-LDL) and serum copper-zinc superoxide dismutase(CuZnSOD)in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) and obstructive sleep apnea-hypopnea associated hypertension(OSAHAHT). Methods]A total of 20 OSAHS patients,20 OSAHAHT patients and 20 health controls were selected.Serum ox-LDL level and CuZnSOD level was determined by enzyme-linked immunosorbent assay and xanthine oxidase,respectively.And they were comparat... |
| Keywords: | Obstructive aleep apnea hypopnea syndrome(OSAHS) Oxidized low-density lipoprotein Copper-zinc superoxide dismutase Hypertension Oxidation and antioxidation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |