| 纳米二氧化钛对大鼠淋巴细胞DNA损伤的影响 |
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| 引用本文： | 冯本秀,徐海娟,杨敏,温薇,陈建雄.纳米二氧化钛对大鼠淋巴细胞DNA损伤的影响[J].职业与健康,2011,27(13):1489-1491. |
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| 作者姓名： | 冯本秀 徐海娟 杨敏 温薇 陈建雄 |
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| 作者单位： | 广东省职业病防治院职业卫生评价所,510030 |
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| 基金项目： | 广东省医学科研基金立项课题 |
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| 摘 要： | 目的探讨纳米二氧化钛(TiO2)对大鼠淋巴细胞DNA的损伤作用。方法采用不同剂量(0、8、16、32 mg/kg)的纳米TiO2对大鼠进行染毒24 h,通过碱性彗星试验观察淋巴细胞DNA的损伤。结果当剂量达到32 mg/kg时与阴性对照组比铰,差异有统计学意义(P<0.05)。结论纳米TiO2可导致人鼠淋巴细胞DNA的损伤。
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| 关 键 词： | 纳米二氧化钛 淋巴细胞 DNA损伤 |
DNA Damage of Lymphocytes of Rat Induced by Nano TiO2 |
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| FENG Ben-xiu,XU Hai-juan,YANG Min,WEN Wei,CHEN Jian-xiong.DNA Damage of Lymphocytes of Rat Induced by Nano TiO2[J].Occupation and Health,2011,27(13):1489-1491. |
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| Authors: | FENG Ben-xiu XU Hai-juan YANG Min WEN Wei CHEN Jian-xiong |
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| Institution: | FENG Ben-xiu,XU Hai-juan,YANG Min,WEN Wei,CHEN Jian-xiong(Guangdong Hospital for Occupational Disease Prevention and Treatment,Guangzhou,510030,China) |
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| Abstract: | Objective]To explore the DNA damage induced by Nano-TiO2 in lymphocytes of rat.Methods]Rats were exposed to different doses of NanoTiO2(0,8,16,32 mg/kg) for 24 hours.DNA damage of lymphocytes was observed with comet assay.Results]There was significant difference of DNA damage compared with the negative controls when the doses of NanoTiO2 was 32 mg/kg(P<0.05).Conclusion]Nano TiO2 could induce DNA damage of lymphocytes of rats. |
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| Keywords: | Nano TiO2 Lymphocytes DNA damage |
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