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环氧化酶-2在大肠癌的表达及意义
引用本文:高伟敏,檀艳丽,薛娟,刘书哲,韩彩丽. 环氧化酶-2在大肠癌的表达及意义[J]. 河北职工医学院学报, 2010, 27(3): 9-11
作者姓名:高伟敏  檀艳丽  薛娟  刘书哲  韩彩丽
作者单位:1. 河北大学基础医学院,病理教研室,河北,保定,071000
2. 河北医科大学,病理教研室,河北,石家庄,050017
基金项目:河北省医学科学研究重点课题计划项目 
摘    要:目的探讨环氧化酶-2(COX-2)在大肠癌组织中的表达及其与肿瘤恶性程度、分级的关系。方法采用免疫组化技术检测5例正常肠组织、68例大肠癌组织中COX-2的表达情况。结果 68例大肠癌组织COX-2的表达阳性率为61.2%(42/68),显著高于切缘正常组织0%(P〈0.05)。COX-2的表达强度和大肠癌的病理分级呈正相关(χ^2=8.045,P〈0.05)。结论 COX-2在大肠癌形成、演化过程中起重要作用。

关 键 词:大肠癌  环氧化酶-2  免疫组化

Expression and its pathological significance of COX-2 in human colorectal cancer
Gao Weimin,Tan Yanli,Xue Juan,et al.. Expression and its pathological significance of COX-2 in human colorectal cancer[J]. Journal of Hebei Medical College for Continuing Education, 2010, 27(3): 9-11
Authors:Gao Weimin  Tan Yanli  Xue Juan  et al.
Affiliation:Gao Weimin,Tan Yanli,Xue Juan,et al. (School of Basic Medical Science of Hebei University,Baoding 071000,China)
Abstract:Objective To evaluate the expression of Cyclooxygenase-2 (COX-2) in human colorectal cancer in order to explore its clinical pathological significance. Methods The expression of COX-2 in the 68 colorectal cancer and normal intestinal tissue were studied with SP immunohistochemical staining. Results No positive expression of COX-2 was found in normal intestinal tissue, while the positive cytoplasmic expression rate of COX-2 in colorectal cancer cases was 61.2%, which was significantly higher than that in nor...
Keywords:colorectal cancer  Cyclooxygenase-2  immunohistochemistry  
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