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Elevated B cell-activating factor (BAFF) in children with allergic rhinitis
Affiliation:1. Department of Otolaryngology, Guangzhou Women and Children''s Medical Center, Guangzhou Medical College, Guangzhou, China;2. Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;3. Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China;1. Tulane University, Department of Otolaryngology – Head & Neck Surgery, 1430 Tulane Avenue, SL 59, New Orleans, LA 70112, United States;2. Ochsner Health System, United States;1. Department of Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada;2. Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Nova Scotia, Canada;3. IWK Health Centre, Dalhousie Pediatric Craniofacial Group, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada;4. School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada;1. İzmir Katip Çelebi University Atatürk Research and Education Hospital, Otolaryngology Head and Neck Surgery Clinic, İzmir, Turkey;2. İzmir Aliağa State Hospital, Otolaryngology Head and Neck Surgery Clinic, İzmir, Turkey;3. Mardin State Hospital, Otolaryngology Head and Neck Surgery Clinic, Mardin, Turkey;4. İzmir Katip Çelebi University, Faculty of Medicine, Department of Histology and Embrology, İzmir, Turkey;5. Celal Bayar University, Faculty of Medicine, Department of Histology and Embrology, Manisa, Turkey
Abstract:ObjectiveTo evaluate the possible role of B cell-activating factor (BAFF) in children with allergic rhinitis (AR).MethodsTwenty-four AR children and 20 normal children were enrolled in this study and nasal lavage and serum were collected. The nasal and serum levels of BAFF were measured using enzyme-linked immunosorbent assay (ELISA). The relationship between serum BAFF and immunoglobulin A (IgA) was evaluated in AR children.ResultsOur results showed that the nasal and serum levels of BAFF were significantly increased in AR children compared with controls (p < 0.05). The nasal and serum levels of BAFF in AR children were significantly associated with disease severity (p < 0.05). Moreover, the level of serum BAFF was negatively related to serum IgA level (p < 0.05).ConclusionOur findings show BAFF expression was significantly increased and related to disease severity, indicating BAFF may be implicated in new treatment modalities for AR children.
Keywords:Allergic rhinitis  Children  Disease severity  B cell-activating factor  Immunoglobulin A
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