Neonatal manipulation of oxytocin prevents lipopolysaccharide-induced decrease in gene expression of growth factors in two developmental stages of the female rat |
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| Affiliation: | 1. Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia;2. Institute of Physiology, Medical Faculty, Comenius University, Bratislava, Slovakia;3. Department of Normal and Pathological Physiology, Medical Faculty, Slovak Medical University, Bratislava, Slovakia;1. Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States;2. Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27704, United States;3. Department of Microbiology, University of Tennessee, Knoxville, TN 37996, United States;4. Department of Surgery, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN 37920, United States;1. Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-106 Warsaw, Poland;2. Department of Pathophysiology, Immunology and Pathology, Institute of Rheumatology, Warsaw, Poland;1. Dept. Pharmacology, Faculty of Medicine and Odontology, University of the Basque Country, E-48940 Leioa, Vizcaya, Spain;2. Dept. Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, 39011 Santander, Spain;1. School of Electronics and Information, Northwestern Polytechnical University, Xi’an, China;2. State Key Laboratory of ISN, Xidian University, Xi’an, China |
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| Abstract: | Oxytocin production and secretion is important for early development of the brain. Long-term consequences of manipulation of oxytocin system might include changes in markers of brain plasticity – cytoskeletal proteins and neurotrophins. The aim of the present study was (1) to determine whether neonatal oxytocin administration affects gene expression of nestin, microtubule-associated protein-2 (MAP-2), brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the brain of two developmental stages of rat and (2) to evaluate whether neonatal oxytocin administration protects against lipopolysaccharide (LPS) induced inflammation. Neonatal oxytocin did not prevent a decrease of body weight in the LPS treated animals. Oxytocin significantly increased gene expression of BDNF in the right hippocampus in 21-day and 2-month old rats of both sexes. Gene expression of NGF and MAP-2 significantly increased in males treated with oxytocin. Both, growth factors and intermediate filament-nestin mRNA levels, were reduced in females exposed to LPS. Oxytocin treatment prevented a decrease in the gene expression of only growth factors. In conclusion, neonatal manipulation of oxytocin has developmental and sex-dependent effect on markers of brain plasticity. These results also indicate, that oxytocin may be protective against inflammation particularly in females. |
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| Keywords: | Oxytocin MAP-2 Nestin Neurotrophic factors Development |
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