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Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort |
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| Authors: | J Ose R T Fortner H Schock P H Peeters N C Onland-Moret H B Bueno-de-Mesquita E Weiderpass I T Gram K Overvad A Tjonneland L Dossus A Fournier L Baglietto A Trichopoulou V Benetou D Trichopoulos H Boeing G Masala V Krogh A Matiello R Tumino M Popovic M Obón-Santacana N Larra?aga E Ardanaz M-J Sánchez V Menéndez M-D Chirlaque R C Travis K-T Khaw J Br?ndstedt A Idahl E Lundin S Rinaldi E Kuhn I Romieu M J Gunter M A Merritt E Riboli R Kaaks |
| Abstract: | Background:Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.Methods:We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations.Results:We observed no association between IGF-I and EOC overall or by tumour characteristics.Conclusions:In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk. |
| Keywords: | IGF-I ovarian cancer histological subtypes carcinogenesis type I/type II dualistic pathway |