Hearing loss in a pediatric patient following cisplatin chemotherapy and subsequent exposure to excessive noise |
| |
| Affiliation: | 1. Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada;2. Faculté de Médicine de Montpellier, Université Montpellier 1, Montpellier, France;3. Division of Hematology-Oncology, Department of Pediatrics, CHU Sainte-Justine/Université de Montréal, Montreal, Quebec, Canada;1. Department of Otorhinolaryngology—Head and Neck Surgery, Seoul National University College of Medicine, Seoul, South Korea;2. Department of Otorhinolaryngology—Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea;1. Tulane University, Department of Otolaryngology – Head & Neck Surgery, 1430 Tulane Avenue, SL 59, New Orleans, LA 70112, United States;2. Ochsner Health System, United States;1. Genetics Unit, Child''s Institute, University of São Paulo, São Paulo, Brazil;2. St John''s Institute of Dermatology, King''s College London, Guy''s Campus, London, UK;1. İzmir Katip Çelebi University Atatürk Research and Education Hospital, Otolaryngology Head and Neck Surgery Clinic, İzmir, Turkey;2. İzmir Aliağa State Hospital, Otolaryngology Head and Neck Surgery Clinic, İzmir, Turkey;3. Mardin State Hospital, Otolaryngology Head and Neck Surgery Clinic, Mardin, Turkey;4. İzmir Katip Çelebi University, Faculty of Medicine, Department of Histology and Embrology, İzmir, Turkey;5. Celal Bayar University, Faculty of Medicine, Department of Histology and Embrology, Manisa, Turkey |
| |
| Abstract: | Cisplatin is a commonly-used chemotherapeutic agent that is highly-effective against a variety of pediatric cancers. Unfortunately, it may lead to ototoxicity, with serious consequences on the quality of life of survivors. Patients remain at risk of progression of ototoxicity even after completion of treatment. We report the case of a medulloblastoma survivor with previously documented normal hearing, who developed significant hearing loss and tinnitus following exposure to excessive noise at a nightclub three years after completion of treatment. We highlight the importance of long-term audiological follow up and education about the increased risk of hearing loss in this population. |
| |
| Keywords: | Cisplatin Ototoxicity Pediatric oncology Late effects Noise-induced hearing loss Progressive hearing loss |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
