Antenatal corticosteroid therapy: Current strategies and identifying mediators and markers for response |
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| Institution: | 1. Dept of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA;2. Cleveland Clinic, Dept of Radiation Oncology, Taussig Cancer Institute, Cleveland, OH, USA;3. Dept of Radiation Oncology, Beaumont Health System, Royal Oak, MI, USA;1. Center for Reproductive Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200135, PR China;2. Department of Obstetrics, Huaian Maternity and Child Healthcare Hospital Affiliated to Yangzhou University School of Medicine, Huaian 223002, PR China;3. Department of Obstetrics and Gynecology, No. 401 Hospital, Qingdao 266100, PR China;4. Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, TX 78229, USA;1. Department of Production Animal Medicine, University of Helsinki, Saarentaus, Finland;2. Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany;3. Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637 Poznan, Poland |
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| Abstract: | Landmark early work has led to the nearly universal use of antenatal corticosteroids to accelerate fetal lung maturity with pregnancies complicated by impending preterm birth. Antenatal corticosteroids clearly reduce respiratory morbidity, death, and other adverse neonatal outcomes. Limited pregnant human pharmacokinetic data and some animal data give clinicians some information as to the behavior of the drug in the body. However, there is controversy about the type, amount, and frequency of steroid to use for this therapy. This review article summarizes the history, clinical use, and pharmacology of antenatal steroids. In addition, the review highlights some potential mediators of steroid response and current research strategies aimed at possible optimization of this therapy. |
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| Keywords: | antenatal corticosteroids betamethasone preterm birth respiratory distress syndrome pharmacogenetics |
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