头孢呋辛预防肝硬化食管胃静脉曲张内镜治疗术后感染的有效性及临床意义

目的:探讨头孢呋辛预防肝硬化食管胃静脉曲张内镜硬化剂治疗术后感染的有效性及临床意义。方法:前瞻性选择某院2019年3月至8月行内镜硬化剂治疗且满足纳入和排除标准的患者40例,随机分为实验组和对照组,各20例。遵照相关指导原则,实验组于术前30 min静脉滴注1.5 g头孢呋辛,以后每8 h静脉滴注0.75 g头孢呋辛,用药时间不超过24 h;对照组于术后静脉滴注头孢噻肟舒巴坦3 g,q 12 h,疗程3 d。分析两组患者体温及感染相关实验室指标的变化。结果:术前、术后患者体温、WBC、NEUT、NEUT%及PCT比较均无统计学差异(P>0.05),且变化趋势相同(P>0.05)。仅术后24 h CRP及内毒素两组比较存在差异性(P<0.05)。结论:术前应用头孢呋辛在预防内镜硬化剂治疗术后感染方面是有效且可行的,但最终结论尚需大样本进一步研究。

Efficacy of preventive use of cefuroxime on postoperative infection in cirrhosis patients undergoing endoscopic treatment of esophageal and gastric varices

Objective:To investigate the effect of preventive use of cefuroxime on postoperative infection in cirrhosis patients undergoing endoscopic sclerotherapy of esophageal and gastric varices.Methods:According to the inclusion criteria and exclusion criteria,40 patients undergoing endoscopic sclerotherapy of esophageal and gastric varices from March 2019 to August 2019 were prospectively collected and randomly divided into experimental group and control group.There were 20 patients in each group.Based on related guidelines,patients in the experimental group were given 1.5 g cefuroxime sodium intravenously 30 minutes before the operation followed by 0.75 g cefuroxime sodium every 8 hours.The duration of medication was not more than 24 hours.Patients in the control group were given 3 g cefotaxime sodium and sulbactam sodium intravenously every 12 hours for 3 days after operation.Body temperature and infection-related lab indexes of the patients in two groups were collected and analyzed.Results:Body temperature,WBC,NEUT,NEUT%and PCT in two groups showed the same changing trend and had no significant difference(P>0.05).There were significant differences in CRP and endotoxin 24 hours after operation between the experimental group and the control group(P<0.05).Conclusion:It suggested that cefuroxime using before endoscopic sclerotherapy could prevent the occurrence of infection after operation,which needed to be proved by further studies with large samples.