Role of pyroptosis in liver diseases |
| |
| Institution: | 1. Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China;2. Institute of Life Sciences, Wenzhou University, Wenzhou 325035, Zhejiang Province, China;3. Pediatric Research Institute, The Second Affiliated Hospital and Yuying Children''s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China;4. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China;5. Department of Pharmacy, North South University, Bashundhara, Dhaka 1229, Bangladesh;6. Department of Pharmacy, Southeast University, Banani, Dhaka 1213, Bangladesh;7. Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children''s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China |
| |
| Abstract: | Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines. In terms of mechanism, there are two signaling pathways involved in pyroptosis, including caspase-1, and caspase-4/5/11 mediated pathways. However, pyroptosis plays important roles in immune defense mechanisms. Recent studies have demonstrated that pyroptosis plays significant roles in the development of liver diseases. In our review, we have focused on the role of pyroptosis based on the molecular and pathophysiological mechanisms in the development of liver diseases. We have also highlighted targeting of pyroptosis for the therapeutic implications in liver diseases in the near future. |
| |
| Keywords: | Pyroptosis NLRP3 Caspase-1 liver diseases Non-alcoholic fatty liver disease |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
